Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | MEK, ERK-1 and ERK-2 are activated by phosphorylation, tetanus toxin or the C-terminal part of the heavy chain induce phosphorylation of ERK-1 and ERK-2 at Thr202 and Tyr204 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme is involved in the mitogen-activated protein kinase signaling pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | MEK is phosphorylated at Ser217 and Ser221, activating phosphorylation of ERK-1 and ERK-2 at Thr202 and Tyr204 induced by tetanus toxin or the C-terminal part of the heavy chain | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex | - |
Rattus norvegicus | - |
neuron | cultured cortical neurons from fetal brain | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in the mitogen-activated protein kinase signaling pathway | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ERK 1 | - |
Rattus norvegicus |
ERK 2 | - |
Rattus norvegicus |
extracellular-signal-regulated kinase 1 | - |
Rattus norvegicus |
extracellular-signal-regulated kinase 2 | - |
Rattus norvegicus |
MEK | - |
Rattus norvegicus |